The MDA/ALS Newsmagazine - Stories by Topic | Muscular Dystrophy Association

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MDA/ALS Newsmagazine
Vol. 13, No. 10 November-December 2008
Kids make good caregivers, within limits. See “Role Reversal.” Photo by David Ricketts for MDA ALS Caregiver’s Guide.

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Stories by Topic

Research

Clinical Trials

Anti-SOD1 Compound on Path to Clinical Trials (February 2008)

Antioxidants/Oxidative Stress

Researchers Probe Role of Lipid Overload (Oct. 2002)
Oxidative Stress, Copper May Be Wrong Suspects in ALS (April 2002)
Fullerenes May Be Next Major Antioxodants (November 1997)

Communication

Partners Cope When Speech Is Lost (October 2004)
Minority of Long-Term ALS Survivors Lose Communication Ability (Sept. 2003)

Drugs/Trials

Sangamo BioSciences to Test Compound that Boosts VEGF A Protein (October 2008)
MDA-Supported Lithium Study Now Open at 10 Sites (September 2008)
ALS TDI Finds Lithium Ineffective, Apocynin Ambiguous in ALS Mice (September 2008)
High-dose Coenzyme Q10 Showed No Benefit (June 2008)
Phase 2 Study of KNS-760704 is Open (June 2008)
MDA-Funded Lithium Trial is Now Open (June 2008)
People with ALS Face Tough Decisions About Experimental Medications (April 2008)
FDA Confirms Rat Study Results are Reason for Arimoclomol Trial Hold (April 2008)
Arimoclomol Trial on Hold (March 2008)
MDA to Fast-track Lithium Trial (March 2008)
Avanir Opens Phase 3 Trial of PBA Drug (February 2008)
CytRx to Test Arimoclomol at Higher Dose (February 2008)
Ritonavir Eliminated, but Hydroxyurea May be Worth Closer Look (January 2008)
Celecoxib and Creatine Combination May Warrant Further Testing (January 2008)
Large-scale Minocycline Trial Showed Drug is Harmful in ALS (January 2008)
Ceftriaxone Trial Still Open (November-December 2007)
Knopp Neurosciences to Pursue Development of 'Mirror-Image' Molecule (November-December 2007)
Emotional-control Drug Development to Move Forward (October 2007)
ALS-Statin Interactions Probed (September 2007)
Are SOD1 Mice Good Models of Human ALS? (July 2007)
Sodium Phenylbutyrate Passes Safety Trial (June 2007)
Minocycline Doesn't Slow ALS Progression (June 2007)
Avanir Meets With FDA on Zenvia (April 2007)
MDA Part of Historic $36 Million Drug Search (Feb. 2007)
Ceftriaxone Trial Seeks Participants (Feb. 2007)
Two New Compounds Target Cell Death by Mitochondria (Feb. 2007)
FDA Withholds Approval of Pseudobulbar Affect Drug (Jan. 2007)
Is Generic Rilutek on the Way? (Jan. 2007)
Direct Delivery Gets Around Baclofen Sedation (Jan. 2007)
Selecting Early Responders May Speed Drug Testing (Jan. 2007)
Trial of Anti-Cramping Drug Seeks Patients (Nov.-Dec. 2006)
Modafinil for Fatigue Under Study (Oct. 2006)
Arimoclomol Safety Trial Is Complete (Sept. 2006)
Investigators Testing Variant of Parkinson's Drug (Aug. 2006)
Lipitor Being Tested in Houston (Aug. 2006)
Ceftriaxone Trial Opens at Eight Centers (Aug. 2006)
Combination Drug Trial to Start (June-July 2006)
Anti-Enzyme Compound May Help Preserve Protection (June-July 2006)
Two Meds Are Better Than One (June-July 2006)
New Compound Boosts Glutamate Transport (May 2006)
Mice With ALS Benefit From Thalidomide (May 2006)
FDA Will Allow Ceftriaxone Study (May 2006)
ALS Research: Where Are We Headed? (May 2006)
Creatine Fails Again (March 2006)
Pentoxifylline Not Helpful in ALS (Feb. 2006)
Potent Antioxidant Found Safe, Well Tolerated (Jan. 2006)
Copaxone Results Encourage Investigators (Jan. 2006)
Arimoclomol Multicenter Trial Set to Begin (Dec. 2005)
Celgene Tries Thalidomide (June 2005)
High-Dose Tamoxifen May Prolong Survival (June 2005)
Cyclosporine Revisited (Feb.-Mar. 2005)
Ceftriaxone Helps Mice (Feb.-Mar. 2005)
Modafinil May Help With Staying Awake (Feb.-Mar. 2005)
Novartis Drug Fails ALS Test (Feb.-Mar. 2005)
Report Shows Tamoxifen Safe, Maybe Beneficial (Jan. 2005)
High-Dose CoQ10 Looks Safe in Long-Term Study (Jan. 2005)
Celebrex Fails ALS Test (December 2004)
Parkinson's Drug Helps Mice With ALS (November 2004)
Avanir Still Seeks Volunteers for Neurodex Study (November 2004)
Xaliproden Fails in ALS, But Hope Remains (October 2004)
CoQ10 Still on Trial (October 2004)
Trial of MS Drug Opens in New York (glatiramer acetate) (Aug./Sept. 2004)
Minocycline Shown Relatively Safe in Early Trials (July 2004)
Indinavir Shown Ineffective in ALS (June 2004)
Blood Biomarkers Need Study Participants (June 2004)
Study of New Compound Open (TCH 346) (Feb. 2004)
Study Finds No Benefit From Creatine in ALS (Dec. 2003)
Riluzole Revisited: When and How Much? (Dec. 2003)
Marijuana Relieves ALS Symptoms, Survey Suggests (Dec. 2003)
Minocycline Study Finally Opens (Nov. 2003)
Researchers at Neurology Meeting Explore SOD1, New Drugs, Stem Cells (May 2003)
MS Drug Shows Promise Against ALS (May 2003)
Multidrug Approach Gains Momentum (April 2003)
'Drug Cocktail' Shown Doubly Effective Against ALS in Mice (Feb. 2003)
Researchers Probe Marijuana in ALS (Feb. 2003)
Pentoxifylline Under Study in Europe (Feb. 2003)
Topiramate Shows No Benefit in ALS (Jan. 2003)
ALS Researchers Meet in Melbourne and Review Drug Progress (Dec. 2002)
Scientists Report Progress Toward Drug Therapies (Dec. 2002)
Third Trial Needed to Judge Myotrophin (Sept. 2002)
Trials Help Scientists Take Small Steps to Big Goals, New Mexico Director Says (Aug. 2002)
Avicena Wants to Market Cratine as Orphan Drug (Aug. 2002)
Drug for Emotional Instability Shows Promise (Aug. 2002)
Riluzole's Benefits Hold Up Under Scrutiny (Aug. 2002)
Rilutek Safe but Weak; Better Drugs May Be on the Way (May 2002)
Rilutek Assistance (February 2002)
Sprouting Neurons (Dec. 2001)
Vitamin E Might Help a Little (August 2001)
First Look Suggests Some Benefit From CoQ10 (June 2001)
Study of Buspirone for Respiratory Impairment Under Way at Two Centers (April 2001)
Creatine Risks Noted by French Agency (February 2001)
No Merit to Purported Benefits of Snake Venom (October 2000
Study Suggests Loss of Zinc From SOD1 Common Trigger for All ALS (February 2000)
Blood Tests to Check Liver Urged for Those on Riluzole (June 1999)
MDA-Associated Doctors Respond to Riluzole Liver Issues (June 1999)
Amgen Drops GDNF Program, Continues BDNF Study (June 1999)
Use Caution With Creatine (June 1999)
Supplement Found Beneficial in ALS (April 1999)
New Product May Help Control Crying, Laughing in ALS (April 1999)
Drugs for ALS -- Where Are We Now? (February 1999)
Penicillamine Not Helpful So Far in Genetic ALS (December 1998)
Coenzyme Q10 Saves Nerve Cells in Mice With ALS (October 1998)
Experts Meet on Combination Trials (April 1996)
MDA Researcher's Mouse Shows Value of Drugs (February 1996)
MDA, Amgen Discuss ALS Drug Trials (February 1996)
MDA Lays Groundwork for Combination Drug Trials (January 1996)

Epidemiology

VA Broadens ALS Care Coverage While Studies of Veterans Continue (September 2008)
Study Suggests Gulf War-Associated Increase in ALS is Time-Limited and Correlated with Location (September 2008)
Researchers Probe Possible Links Between Genes and Exposures to Toxins (May 2008)
Review of Evidence Supports Link Between Toxic Exposures and Illness in Gulf War Vets (April 2008)
ALS and Vets: Searching for Connections (March 2008)
Veterans With ALS Study Wants You (April 2007)
Report Concludes Military Tie Deserves Further Study (Jan. 2007)
Studies Probe ALS Risk, Severity (Nov.-Dec. 2006)
Study Will Bank Data and Biomaterial (Oct. 2006)
CDC Gets $900,000 to Start ALS Registry (April 2006)
Large-Scale ALS Factors Study Enters Phase 2 (Jan. 2006)
MDA-Funded ALS Registry Now Online (Jan. 2006)
National ALS Database Proposal Before Congress (Sept. 2005)
VA Changes Web Site for ALS Registry (Aug. 2005)
Studies Examine Genetic and Environmental Factors (July 2005)
Long-Ago Residence on Guam Is Likely ALS Risk Factor (July 2005)
No Correlations Found in Corn Belt Study (May 2005)
Vitamin E, Military Service May Affect ALS Risk (April 2005)
ALS Epidemiology Study Under Way (April 2005)
Physical Activity Affects ALS Onset But Not Risk (Feb.-Mar. 2005)
Gulf War Report Available Online (Jan. 2005)
Military Service Is Apparent ALS Risk Factor (June 2004)
Smoking Is Likely ALS Risk Factor (April 2004)
Studies Show . . .Part 4 in a series; Questions, Common Sense Help Dissect Study Findings (Jan. 2004)
Studies Show . . . Part 3 in a series; It's Different — But Is It 'Significant'? (Dec. 2003)
Studies Show . . . Part 2 in a series; Cluster or Clutter? (Nov. 2003)
Gulf War Vets More Likely to Get ALS (Oct. 2003)
Studies Show ... (Oct. 2003)
Disappointed With Kelly AFB Study (April 2003)
Online Government Site Compiles Gulf War-Related Research (August 2002)
'Living With ALS' Study Extended (Oct. 2003)
Narcotics, NSAIDS Might Affect ALS Risk (May 2003)
'Corn Belt' Study Expands Across United States (Jan. 2003)
No ALS 'Cluster' Found at Kelly Air Force Base (December 2002)
VA Studies Show ALS Link to Gulf War (December 2002)
Insecticide Exposure in Corn Belt Under Study (Oct. 2002)
New Study Explores Connection Between Athletics and ALS (June 2002)
Bats and Nuts Yield Environmental Clue to ALS on Guam (May 2002)
Unlocking the Mysteries of Guamanian ALS (Feb. 2002)
Gulf War Vets Have Higher ALS Risk (December 2001)
Texas ALS Cluster Could Be 'Incredibly Important,' Experts Say (December 2000)
Many With ALS Live Longer Than Books Say (June 2000)
Government to Explore Potential Link Between ALS and Gulf War (April 2000)
Genetic Predisposition to Gulf War Syndrome Found (August 1999)
Is There a Gulf War Connection to ALS? (April 1999)

Exercise

Strenuous Lifestyle May Increase ALS Susceptibility (January 2008)
Exercise Your Options (October 2007)
Supervised Resistance Exercise Slowed Functional Loss in Small Study (September 2007)
Mouse Studies Say Exercise, Hormone Levels May Influence ALS Course (Nov. 2003)
Exercises to Do on the Run: Simple Ways for Caregivers to Resist Injury (Oct. 2003)
Exercise Beneficial to Mice with ALS (July 2003)
Exercise Has Many Benefits for People With ALS (October 2002)

General

ALS Registry Act Passed (Nov.-Dec. 2008)
FDA Finds No Connection Between Statins and Increased ALS Risk (Nov.-Dec. 2008)
MDA/ALS Centers to Help ALS TDI Identify ALS ‘Signature’ (October 2008)
UC Irvine Professor Seeks People Who May Have Rare Muscle and Bone Disorder (October 2008)
Biomarker Study Opens Across U.S. (October 2008)
Scientists Create Nerve Cells from Skin Cells of Woman with ALS (October 2008)
Flaws in Detoxifying Enzymes Again Implicated in ALS Susceptibility (October 2008)
MDA/ALS Center Directors Produce Collection of Articles About ALS (September 2008)
FDA Approves Diaphragm Pacing System to Treat People with Spinal Cord Injuries (September 2008)
Umbilical-Cord Blood Cells May Have Therapeutic Potential in ALS (September 2008)
VA Broadens ALS Care Coverage While Studies of Veterans Continue (September 2008)
ALS TDI Finds Lithium Ineffective, Apocynin Ambiguous in ALS Mice (September 2008)
Study Suggests Gulf War-Associated Increase in ALS is Time-Limited and Correlated with Location (September 2008)
A Bridge Between Two Worlds (July-August 2008)
Leaks in Blood-Spinal Cord Barrier Come Before Nervous-System Damage in Mice with SOD1 ALS (June 2008)
High-dose Coenzyme Q10 Showed No Benefit (June 2008)
Phase 2 Study of KNS-760704 is Open (June 2008)
MDA-Funded Lithium Trial is Now Open (June 2008)
People with ALS Sustain Hope with Variety of Strategies (May 2008)
Researchers Probe Possible Links Between Genes and Exposures to Toxins (May 2008)
ALS-causing Flaws in TDP-43 Gene Found in Two New Studies (May 2008)
Does a High Serum Cholesterol Level Increase Survival Time in ALS? (May 2008)
Review of Evidence Supports Link Between Toxic Exposures and Illness in Gulf War Vets (April 2008)
VEGF-B May Save Nerve Cells Without Collateral Damage (April 2008)
Nerve-muscle Signals are a Two-way Street (April 2008)
What’s Going on with TDP-43? (April 2008)
FDA Confirms Rat Study Results are Reason for Arimoclomol Trial Hold (April 2008)
ALS and Vets: Searching for Connections (March 2008)
XMRV not an ALS Contributor (March 2008)
Genes Involved in Axon Guidance Implicated in ALS (March 2008)
Looking Outside Nerve Cells for Causes of ALS (March 2008)
Anti-SOD1 Compound on Path to Clinical Trials (February 2008)
Avanir Opens Phase 3 Trial of PBA Drug (February 2008)
Laughing/Crying Episodes More Common Than Once Thought (February 2008)
ALS TDI Collaborating with Aptagen to Develop ALS-specific 'Bullets' (February 2008)
Protecting Nerve-muscle Junctions may Protect Nerve Cells (February 2008)
Multinational Study Implicates DPP6 Gene Variant as Risk Factor for ALS (February 2008)
CytRx to Test Arimoclomol at Higher Dose (February 2008)
Multiple Serious Head Injuries May Increase Risk of ALS (January 2008)
Portable Device Might Make Trials Easier for Participants (January 2008)
Nose May Provide Window to Brain (January 2008)
Strenuous Lifestyle May Increase ALS Susceptibility (January 2008)
Dutch Study Warns Against Chinese Stem-cell Treatments (January 2008)
Ritonavir Eliminated, but Hydroxyurea May be Worth Closer Look (January 2008)
Celecoxib and Creatine Combination May Warrant Further Testing (January 2008)
Large-scale Minocycline Trial Showed Drug is Harmful in ALS (January 2008)
ALS Specialists Discuss Clinical Trial Results, Methods at Toronto Conference (January 2008)
Helping Hands - Caring for Others Comes With a Price and a Reward (November-December 2007)
Ceftriaxone Trial Still Open (November-December 2007)
Researchers Probe Use of MRIs in Diagnosing ALS-related Cognitive Decline (November-December 2007)
Knopp Neurosciences to Pursue Development of 'Mirror-Image' Molecule (November-December 2007)
Progranulin Deficiency Leads to Toxic TDP-43 Behavior (November-December 2007)
New Studies Strongly Support ALS-Angiogenin Connection (November-December 2007)
Human Stem Cells Secreting GDNF Protected Dying Motor Neurons (October 2007)
Researchers are 'Beating the Bushes' at ALS TDI (October 2007)
Supervised Resistance Exercise Slowed Functional Loss in Small Study (September 2007)
TGen Whole-Genome Results Published (September 2007)
ALS-Statin Interactions Probed (September 2007)
ALS TDI Says Tighter Controls Needed in Mouse Studies (September 2007)
Are SOD1 Mice Good Models of Human ALS? (July 2007)
TDP-43 Protein's Absence May Mean SOD1 ALS is Different (July 2007)
New Method Identifies Toxic SOD1 (July 2007)
Life Satisfaction Similar With and Without Disability (July 2007)
Origin of Viral Protein In ALS Serum Samples Remains Elusive (July 2007)
Research Links Hospice Care With Prolonged Life (July 2007)
Sodium Phenylbutyrate Passes Safety Trial (June 2007)
When It's 'Almost ALS,' Will the Disease Progress? (June 2007)
Tracking ALS Incidence Across Ethnic Groups Shows Possible Variation (May 2007)
End-of-Life Distress Varies by Country (May 2007)
Genetic and Environmental Factors Study Half Full (May 2007)
Living With ALS Study Has Moved (April 2007)
Canadian Group Makes Nerve Cells From Skin (April 2007)
Do Neurons Have a Unique Stress Response? (April 2007)
Stimulating the Diaphragm May Have Merit After All (Jan. 2007)
Device Allows Thought Control of Computer (Nov.-Dec. 2006)
Brain-Computer Interfaces: Is Deeper Better? (Sept. 2006)
Treating Non-Neuronal Cells May Be Good Option in ALS (Sept. 2006)
'Detox' Enzyme DNA Links Genes, Environment, ALS (Aug. 2006)
ALS Community Exchanges Ideas at AAN Meeting (June-July 2006)
Cognitive Impairment Found in 12 of 20 With ALS (May 2006)
Spinal Fluid Protein Levels Useful in ALS Diagnosis (April 2006)
Canadian Group Recreates Cellular Neighborhood (Dec. 2005)
Low SMN Levels Increase ALS Risk and Severity (Oct. - Nov. 2005)
Arimoclomol May Combat Misfolded Proteins (August 2005)
Probing Nogo, High and Low (June 2005)
New Drug Class Targets Cell Death (May 2005)
Spinal Fluid Changes Appear Specific to ALS (Jan. 2004)
How Motor Neurons Die (Nov. 2002)
Bile Acid's Nicer Side (Sept. 2002)
Better Care Needed at End of Life (Sept. 2002)
What Causes ALS? (June 2001)
Protein Clumps May Be Guilty in ALS (June 2001)
Theory May Brighten Outlook for Treating Late Stages (August 2000)
NINDS Director Advocates Combined Approach in ALS Research (June 2000)
Why Motor Neurons Die: Putting the Pieces Together (December 1999)
Multiple Problems May Cause Motor Neurons to Die (December 1999)
Study Shows Adults Can Make New Brain Cells (December 1998)

Genetics/Gene Therapy

Sangamo BioSciences to Test Compound that Boosts VEGF A Protein (October 2008)
UC Irvine Professor Seeks People Who May Have Rare Muscle and Bone Disorder (October 2008)
Flaws in Detoxifying Enzymes Again Implicated in ALS Susceptibility (October 2008)
Research Roundup: Getting Past Barriers (July-August 2008)
Researchers Probe Possible Links Between Genes and Exposures to Toxins (May 2008)
ALS-causing Flaws in TDP-43 Gene Found in Two New Studies (May 2008)
What’s Going on with TDP-43? (April 2008)
Genes Involved in Axon Guidance Implicated in ALS (March 2008)
Protecting Nerve-muscle Junctions may Protect Nerve Cells (February 2008)
Multinational Study Implicates DPP6 Gene Variant as Risk Factor for ALS (February 2008)
ALS Specialists Discuss Clinical Trial Results, Methods at Toronto Conference (January 2008)
Progranulin Deficiency Leads to Toxic TDP-43 Behavior (November-December 2007)
New Studies Strongly Support ALS-Angiogenin Connection (November-December 2007)
Researchers are 'Beating the Bushes' at ALS TDI (October 2007)
TGen Whole-Genome Results Published (September 2007)
NIH Group Finds No Clear DNA Clues to ALS (April 2007)
SOD1 Blocker Moves Toward Human Trials (Feb. 2007)
Gene ID May Unlock New Door to Glutamate Control (Feb. 2007)
Nonviral Gene Delivery Comes of Age (Jan. 2007)
Genome-Wide Scans Provide Scientists First Clues (Nov.-Dec. 2006)
Antisense Reduces SOD1, Prolongs Survival in Rats (Sept. 2006)
'Detox' Enzyme DNA Links Genes, Environment, ALS (Aug. 2006)
ALS With Dementia Linked to Chromosome 9 (May 2006)
Angiogenin Mutations Liklely Boost ALS Susceptibility (April 2006)
Gene 'Flavor' Differences Likely to Provide Valuable Data (April 2006)
Neurodegeneration Appears Tied to Molecular Motor Breakdowns (March 2006)
Wobbler Mouse Gene ID May Unlock New Doors (March 2006)
How Do SOD1 Mutations Kill Nerve Cells? (Feb. 2006)
Large-Scale ALS Factos Study Enters Phase 2 (Jan. 2006)
Spastin Gene Implicated in Juvenile-Onset ALS (Sept. 2005)
Genetic Background Delays ALS Onset in Mice (August 2005)
What Can (and Can't) We Learn From the SOD1 Mouse? (July 2005)
Researchers Block SOD1 Protein in ALS Mice (June 2005)
Emory Center to Study Familial ALS (May 2005)
Hairpin RNA Keeps SOD1 Away (May 2005)
Group IDs SOD1 Blockers (May 2005)
Researchers Target SOD1-Linked Familial ALS (May 2005)
Gene Therapy for ALS — Where Are We Now? (April 2005)
Iron Overload Gene May Be Risk Factor (December 2004)
Cellular Transport Protein Implicated (November 2004)
Peripherin Gene Implicated in ALS (Aug./Sept. 2004)
Patriarch's Energy and Curiosity Aid Gene Search (May 2004)
Gene Found for Early-Onset ALS (May 2004)
German Researchers Find No ALS Connection in 'Detox' Genes (Oct. 2003)
Chromosome 16 Finding Goes Beyond the Obvious (Oct. 2003)
New ALS Gene Mapped to Chromosome 16 (Sept. 2003)
Genetics and ALS (Genetic test) (July 2003)
Abnormal Chromosomes Might Be ALS Risk Factors (June 2003)
Researchers at Neurology Meeting Explore SOD1, New Drugs, Stem Cells (May 2003)
Move Over, SOD1... (April 2003)
Gene Behind pmn May Hold Clues to ALS (Jan. 2003)
Researchers Seek Families With 'ALS Plus' (Sept. 2002)
Evidence Mounts for Minocycline in ALS, With Caution (June 2002)
Gene Therapy for ALS A Step Closer to Reality (May 2002)
Rats With ALS (Dec. 2001)
New Genes (Dec. 2001)
Synthetic Gene (Dec. 2001)
Second ALS Gene Discovered (October 2001)
ALS Gene Hunt Increases in Speed and Scope (August 2001)
New Gene Implicated in Familial ALS (June 2001)
Researcher Explores Genetic Influences on ALS Risk (December 2000)
MDA Researchers Tracking Down New ALS Gene (October 2000)
Old Enemy Becomes New Ally in Gene Therapy (October 2000)
Genetic Predisposition to Gulf War Syndrome Found (August 1999)
Gene Therapy for ALS? (August 1999)
Researchers Report Mutant SOD1 Protein Activates Glutamate Transporters (June 1999)
New Insights Into Motor Neuron Deaths in SOD1-Linked ALS (February 1999)
New Studies of Genetic Factors in Nonfamilial ALS (February 1999)
Mattingly Family Featured in Life Magazine (October 1998)
New Leads in Sporadic ALS (June 1998)
Gene Mapped for Early-Onset, Slowly Progressive Form of ALS (April 1998)
Genetic Factors Influence Chance of ALS (August 1997)
Genetic Test for SOD1-Linked ALS (August 1997)
SOD1 Mutations Linked to Disease Duration (March 1997)

Glutamate

Gene ID May Unlock New Door to Glutamate Control (Feb. 2007)
New Compound Boosts Glutamate Transport (May 2006)
Ceftriaxone Helps Mice (Feb.-Mar. 2005)
Glutamate Transporters — an Untapped Resource? (October 2004)
Studies Strengthen Role of Glutamate, Abnormal RNA (April 2004)
New Anti-Glutamate Drugs (May 2003)
Neurons and Glia Engaged in Vicious Cycle? (May 2003)
Study of ALS Rat Supports Glutamate Toxicity Idea (Feb. 2002)
Glutamate Transporter Could Be Key to Better Drugs (December 2001)
Researchers Report Mutant SOD1 Protein Activates Glutamate Transporters (June 1999)
What About MSG? (August 1997)
Study Supports Glutamate 'Poisoning' in ALS (December 1996)

Immune System

T-Cells Provide Protection in ALS Mice (Nov.-Dec. 2008)
Scientists Create Nerve Cells from Skin Cells of Woman with ALS (October 2008)
Looking Outside Nerve Cells for Causes of ALS (March 2008)
ALS-Statin Interactions Probed (September 2007)
Outside Agitators, Protectors of the Peace or Innocent Bystanders: Microglia (Feb. 2007)
Cyclosporine Revisited (Feb./Mar. 2005)
Immune System Chemical (Dec. 2001)

Neurotrophic (Growth) Factors

Supercharged Stem Cells Save Nerve Cells, Lengthen Life Span in ALS Rats (Nov.-Dec. 2008)
Stem Cells Entered Nervous System but Didn't Slow ALS (Nov.-Dec. 2008)
Scientists Create Nerve Cells from Skin Cells of Woman with ALS (October 2008)
VEGF: Where Do We Go From Here? (Oct. 2006)
No VEGF Variants Found in North American ALS Patients (Oct. 2006)
MDA Seeks to Move Gene Therapy to Clinical Trials (Oct. - Nov. 2005)
IGF1 With Exercise Improves Survival, Function in Mice (June 2005)
VEGF Protein Infusion Helps Rats With ALS (Jan. 2005)
VEGF Protein Helps ALS-Affected Mice (November 2004)
Support for VEGF Treatment Grows (July 2004)
VEGF Deficiency Implicated in Second Disease (April 2004)
Lab Mice Benefit From IGF-1 Gene Transfer (Sept. 2003)
VEGF Deficiency Increases ALS Risk (Aug. 2003)
A New and Improved Neurotrophic Factor? (Sept. 2002)
BDNF Fails to Change Course of ALS (February 2001)
Pilot Study of BDNF Complete (June 2000)
Amgen Drops GDNF Program, Continues BDNF Study (June 1999)
Getting There: More Than Half the Battle in Treating CNS Disease: Biotech Companies, Universities Team Up to Bypass Blood-Brain Barrier (June 1997)
Direct Spinal Fluid Delivery of CNTF Shows Promise (July 1996)

Stem Cells

Supercharged Stem Cells Save Nerve Cells, Lengthen Life Span in ALS Rats (Nov.-Dec. 2008)
Stem Cells Entered Nervous System but Didn't Slow ALS (Nov.-Dec. 2008)
Scientists Create Nerve Cells from Skin Cells of Woman with ALS (October 2008)
Dutch Study Warns Against Chinese Stem-cell Treatments (January 2008)
Human Stem Cells Secreting GDNF Protected Dying Motor Neurons (October 2007)
'Toxic Neighbors' Likely Kill Nerve Cells, At Least in SOD1-Caused ALS (June 2007)
Human Stem Cells Benefit Rats With ALS (Nov.-Dec. 2006)
Stem Cells Come From New Sources (Oct. 2006)
Mouse Stem Cells Treat Paralysis in Rats (Aug. 2006)
Umbilical Cord Blood Stem Cells to Be Tested (Jan. 2006)
Are We There Yet? Stem Cell Therapies for ALS (Dec. 2005)
Beijing Report: Fetal Cells Fail to Stop ALS (Oct. - Nov. 2005)
Embryonic Stem Cells Can Become Motor Neurons (April 2005)
EmCell Investigation Shows Poor Results (November 2004)
Stem Cells Help Regrow Nerves in Rats (Jan. 2004)
Stem Cells May Fuse With Some Brain Cells (Dec. 2003)
Stem Cells Safely Injected in Italy (Dec. 2003)
Human Umbilical Cord Blood Cells Help Mice With ALS (Sept. 2003)
Drugs, Stem Cells, Trial Designs, National Consortium Occupy ALS Experts at June Meeting (July 2003)
Stem Cells Might Help in Unexpected Way (Aug. 2003)
Researchers at Neurology Meeting Explore SOD1, New Drugs, Stem Cells (May 2003)
Neuronal Stem Cells Found in Blood (March 2003)
From Bone Marrow to Brain (Feb. 2003)
MDA Seeks Researchers to Conduct Cord Blood Trial (Jan. 2003)
Scientists Debate Therapeutic Potential of Bone Marrow Stem Cells (Oct. 2002)
Scientists Find Way to Turn Stem Cells Into Motor Neurons (Sept. 2002)
Stem Cell Research Stymied by Red Tape and Controversy (Sept. 2002)
Baylor Center Director Tries Transplanting Bone Marrow in ALS (Sept. 2002)
Potent Stem Cells Found in Bone Marrow (July 2002)
Cord Blood: Banking on a Cure (July 2002)
Ukrainian Clinic 'Stem Cell Treatment' Probed (July 2002)
Stem Cell Therapy Research Taking Several Paths (December 2001)
Stem Cell Research Shows Continued Promise — and Some Surprises (August 2001)

Stress

Strenuous Lifestyle May Increase ALS Susceptibility (January 2008)
Caregivers May Be More Discouraged Than People With ALS (May 2007)
ALS Patients and Caregivers Overrate One Another's Stress (July 2004)
Writing About Events May Lower Caregiver Stress (Feb. 2004)
Reducing Caregiver Stress May Help Loved One's Depression (Feb. 2003)
Stress and ALS (October 2001)

Ventilation/Assistive Devices

FDA Approves Diaphragm Pacing System to Treat People with Spinal Cord Injuries (September 2008)
Portable Device Might Make Trials Easier for Participants (January 2008)
Thinking Outside the Ventilation Box (September 2007)
Oscillation Vest Fails to Slow Respiratory Decline (Oct. 2006)
Noninvasive Ventilation Prolongs Life in ALS (Oct. 2006)
Nutrition and Respiratory Support Investigated (June-July 2006)
NIV Improves Quality of Life, Longevity (May 2006)
Who Tolerates Noninvasive Ventilation? (Feb. 2006)
Does Diaphragm Stimulation Work in ALS? (Sept. 2005)
Study of NIPPV and Nutrition Under Way (August 2005)
Diaphragm Stimulation Study Open in Cleveland (December 2004)
Airway Clearance Vest Under Study in ALS (Oct. 2003)
A Tale of Two Vent Choices (Aug. 2003)
Small Study Says No Harm, Much Benefit Comes With NIV (Aug. 2003)
Center Director to Be Part of Large ALS Respiratory Study (March 2003)
Noninvasive Ventilation Prolongs Life If Used Right, MDA Clinic Director Says (September 2002)
Studies Question Timing of Ventilation, Feeding Tubes (April 2002)

See also Equipment & Products/Ventilators & Respiratory Devices

Viruses

XMRV not an ALS Contributor (March 2008)
Are Viruses a Trigger for ALS? (August 2005)
Researchers Associate Enzyme With ALS (Feb.-Mar. 2005)
No Enteroviruses Found in ALS-Affected Tissue (June 2004)
HIV Link Could Lead to Anti-viral Therapy for ALS (October 2001)
The ALS/Virus Connection (Feb. 2000)
AIDS Virus May Help Cross Blood-Brain Barrier (October 1999)

Research Process

ALS TDI Says Tighter Controls Needed in Mouse Studies (September 2007)
What Can (and Can't) We Learn From the SOD1 Mouse? (July 2005)
Face-off on Multidrug Trials (January 2005)
Studies Show . . .Part 4 in a series; Questions, Common Sense Help Dissect Study Findings (Jan. 2004)
Studies Show . . . Part 3 in a series; It's Different — But Is It 'Significant'? (Dec. 2003)
Studies Show . . . Part 2 in a series; Cluster or Clutter? (Nov. 2003)
Studies Show ... (Oct. 2003)
Disappointed With Kelly AFB Study (April 2003)
Online Government Site Compiles Gulf War-Related Research (August 2002)
Trials Help Scientists Take Small Steps to Big Goals, New Mexico Director Says (August 2002)
How to Donate Tissue for Research (August 1997)

Major research articles

A Long and Winding Road: The Year in Research (May 2008)
ALS Research — The Beat Goes On (May 2005)
Gene Therapy for ALS — Where Are We Now? (April 2005)
ALS Research — Where We've Been, Where We Are Now (December 2004)
Glutamate Transporters — an Untapped Resource? (October 2004)
Support for VEGF Treatment Grows (July 2004)
Gene Found for Early-Onset ALS (May 2004)
Studies Strengthen Role of Glutamate, Abnormal RNA (April 2004)
New Studies Support Roles of Inflammation, Oxidative Stress in ALS (March 2004)
Naturally Speaking: Voice Synthesis Study Advances (Feb. 2004)
Award-Winning MDA Grantee Probes Brain Connections (Dec. 2003)
Motor Neuron Neighbors Help Fight ALS (Nov. 2003)
Gulf War Vets More Likely to Get ALS (Oct. 2003)
New ALS Gene Mapped to Chromosome 16 (Sept. 2003)
VEGF Deficiency Increases ALS Risk (Aug. 2003)
Abnormal Chromosomes Might Be ALS Risk Factors (June 2003)
'Supply Line' Defects Linked to ALS-Like Disease in Mice (June 2003)
MS Drug Shows Promise Against ALS (May 2003)
Defects in Cell 'Supply Line' Might Be Key, MDA Researchers Find (April 2003)